Lowering the cost while maintaining the highly catalytic performance is greatly beneficial for the development of commercial fuel cells and metal-air batteries. Compared with platinum, palladium holds a stronger oxygen affinity and high abundance on earth, endowing it a promising alternative to platinum in anion-exchange membrane fuel cells. However, the sluggish oxygen reduction reaction of palladium still remains a great issue and requires the design of stable and efficient palladium-based electrocatalysts. Here, we report the solvothermal/hydrothermal reduction method to prepare a series of PdAg_x nanowires. The prepared PdAg_x NWs exhibit hollow structure, which greatly improves the utilization of Pd atoms, offering an outstanding ORR performance. Specifically, PdAg₂ NWs exhibit an onset potential of 0.92 V and mass activity of 350.7 mA mg_Pd⁻¹ at 0.7 V vs. RHE for ORR in 0.1 M KOH solution. This work provides a novel approach for the construction of hollow NWs and their subsequent applications in other electrocatalytic reactions.