Chiral metal surfaces of CO2 electro-reduction catalysts could significantly influence CO2 reduction product species, even able to product amino acids. On the other hand, CISS effects have been started to be applicated in electrocatalysts, which significantly enhancesthe catalytic activity on OER. Thus, it is a promising future for CO2 electro-reduction that employs chiral materials with both chiral surface and CISS effects to enhance the catalytic activity of catalysts. In order to achieve this goal, the most critical issue to be addressed is the synthesis of copper materials with highly oriented and ordered chiral helical structures.