In summary, the dynamic migration of indium plays a pivotal role in the formation of stable single-atom RhIn cluster catalysts within zeolite matrix. The unique RhIn@S-1 catalyst discovered by Wang and co-workers effectively prevents metal sintering, which is a great challenge in the field of heterogeneous catalysis. The newly-developed Rh-based catalyst beyond Pt- and Cr-based catalysts ensures an unprecedented lifetime of alkane dehydrogenation. Compared to current commercial catalysts, the lifespan of catalysts has increased by 1–2 orders of magnitude, avoiding the frequent regeneration and complex operating procedures, holding immense potential for future large-scale applications. Furthermore, the mechanistic findings represent a significant leap forward in catalysis and lay a solid foundation for the deliberate design of efficient and durable catalysts for various catalytic processes.