Bharathi Natarajan, Palanisamy Kannan*, Longhua Guo*
Chin. J. Struct. Chem., 2024, 43: 100349. DOI: 10.1016/j.cjsc.2024.100349
September 15, 2024
ABSTRACT
Fascinating
physico-chemical features functionalized metallic nanoparticles (MNPs) enabled
a high surface-to-volume ratio, biocompatibility, and flexible functionalities,
are considered as potential building blocks in functionalized
nano/biointerface, which facilitating stable biosensing detection response
towards the various biological analytes. The MNPs-based colorimetric biosensors
have received enormous attention in chemistry, biology, and medicine owing to
its easiness, practicality, low-cost, highly stable, and selective.
Principally, the colorimetric biosensing is low-cost, it does not require
advanced analytical instrumentations, because the change in color of
nanoparticle dispersion can be directly readout via naked (bare)-eye, which is
indeed used for on-field analysis and point-of-care (POC) analyses. Notably,
MNPs such as gold, silver, iron oxide, and cerium oxide have been used for the
simple and facile colorimetric detection of biologically important analytes via
changes in various colors. In this review, the biosensing mechanism-based on
the change in colors of MNPs toward the detection of clinically important
biomolecules (glucose, ochratoxin A (OTA), etc.,), deoxyribonucleic acid (DNA),
prostate-specific antigen (PSA), alpha-fetoprotein (AFB), lipopolysaccharide
(LPS), carcinoembryonic antigen (CEA), and proteins in various real samples.
This promising discipline, at the interface of nanomaterials and biosciences,
offers extensive projections for interdisciplinary researchers that comprise nanomaterials
preparation, bio-element functionalization, and targeted detection in clinical
diagnostics. The potential approaches for new colorimetric substrate design,
important biosensing characteristics, challenges, and future opportunities on
colorimetric biosensing strategies are also described.