In summary, the precise design of new OER catalysts bearing low cost and acid-resistance remains challenging, thus inevitably hindering the rapid development of PEM electrolyzer in the short run. This inspiring work demonstrates the effectiveness of Fe incorporation in reducing the kinetic barrier of acidic OER process by enhancing water adsorption and dissociation via regulating the electrophilicity of surface oxygen, being of great reference value for exploiting economic OER in acidic conditions. However, some key factors that affect catalytic performance, such as hydrogen spillovers, reduction and oxidation properties of catalysts, should be discussed. With respect to the future research, more efforts are worthy to be devoted to finding alternative non-toxic heteroatoms for the design of high-performance satisfactory low-cost catalysts.