In summary, APMOFs have exhibited great potential for challenging hydrocarbon separations in lab scale by overcoming the trade-off between adsorption capacity and selectivity to a large extent. Nonetheless, several challenges persist for the future deployment of APMOFs in practical industrial separation applications. First, the stability of many APMOFs (eg, SIFSIX-1-Cu) need further improvement; second, the scalability and cost of APMOFs need further consideration; last but not the least, the realistic separation performance under real-word conditions with moisture and more complicated impurities should be evaluated as well.