Just Accepted Articles have been posted online after technical editing and typesetting for immediate view. The final edited version with page numbers will appear in the Current Issue soon.
Although mimicking protein functions using supramolecular systems remains a daunting challenge, the impressive work by Aprahamian etal. suggests that future efforts may focus on nonequilibrium rather than equilibrium states, and that combining dynamic chemistry with host-guest chemistry is a worthwhile direction for creating more complex and biomimetic smart molecules.