A series of novel furan-1,3,4-oxadiazole carboxamide derivatives (5a～5e) were designed, synthesized and characterized by spectroscopic methods including HR-MS, ¹H- and ¹³C-NMR. The crystal structure of compound 5a was determined by single-crystal X-ray diffraction. The compound crystallizes in the triclinic system, space group P with a = 4.7261(5), b = 10.4672(11), c = 14.5886(13) Å, α = 106.081(4)°, β = 91.043(3)°, γ = 99.456(4)°, Z = 2, V = 682.48(12) ų, M_r = 348.16, D_c = 1.694 Mg/m³, S = 1.008, m = 3.025 mm^-1, F(000) = 348, the final R = 0.0775 and wR = 0.2080 for 2774 observed reflections (I > 2σ(I)). There are two kinds of hydrogen bonds (N(3)–H(3A)×××N(2) and C(8)–H(8A)×××O(3)) present in its crystal structure. The preliminary antifungal assay showed that compounds 5b and 5c exhibited significant antifungal activities against several plant pathogenic fungi.