Four novel
2-methoxyimino phenylacetate derivatives containing 1,3,4-oxadiazole ring were
designed and synthesized from the key intermediate of
Trifloxystrobin or
Azoxystrobin via intermediate derivatization and active structure splicing. The chemical
structures of the target compounds were confirmed by
1H NMR,
13C
NMR and elemental analysis. The crystal structure of methyl (E)-2-(methoxyimino)-2-(2-(((5-((4-methoxyphenoxy)methyl)-
1,3,4-oxadiazol-2-yl)thio)methyl)phenyl)acetate (
A1) was determined by
single-crystal X-ray diffraction. Compound
A1 belongs to triclinic system, space group
P with two molecules in each unit cell. The
benzene ring plane C(2)–C(3)–C(4)–C(5)–C(6)–C(7) and oxazole ring
plane are nearly parallel with the dihedral angle of 6.4°. The benzene ring
plane C(12)–C(13)–C(14)–C(15)–C(16)–C(17) and oxazole ring plane are not perpendicular
with the dihedral angle of 49.4°. The crystal of compound
A1 is stabilized by
π-
π stacking
interactions. The
fungicidal activities of the target compounds against four plant pathogenic
fungi in vitro were tested, and some of them had good activities. The DFT calculation was carried out to study the structure-activity relationship of the title
derivatives using Gasian 09 and Multiwfn 3.6.