Surface hydrophilization is required for numbers of applications such as biosensor, biomedical implants and marine coating. However, the preparation of hydrophilic surface from a solid substrate still suffers from limited thicknesses, complex procedures, restricted substrates and harsh conditions. Herein, a method based on in-situ aminolysis of poly(pentafluorophenyl acrylate) (pPFPA) capable of generating arbitrary hydrophilic surface is proposed, enabling high design freedom and abundant choices of hydrophilic molecules. Simply immersing pPFPA coated substrates into 3-((3-aminopropyl)dimethylammonio)propane-1-sulfonate (ADPS), β-alanine and amine-terminal poly(ethylene glycol) (NH₂-PEG) solutions for two hours drastically reduces the water contact angle of the corresponding surfaces, indicating the high efficiency and excellent generality of such method. Systematical studies reveal that these coatings are able to mitigate fog formation, self-clean the oil contaminant and exhibit excellent antifouling performance against algae. Notably, relying on the fast and quantitative feature of the aminolysis, these hydrophilic surfaces possess excellent regeneration capability and well-recover their hydrophilic feature after being physically damaged. This work represents a facile and universal way to fabricate versatile hydrophilic surfaces for multi-functional applications such as self-cleaning, patterning, sensing, antifogging and anti-biofouling.