In summary, the increasing interest in separating lanthanides and actinides for the purposes of spent nuclear fuel reprocessing has spurred renewed research efforts in this domain recently. Although the higher oxidation states of Am have been recognized for several decades, the development of separation techniques based on the control of Am oxidation state remains less advanced. The key challenge in spent fuel reprocessing lies in achieving complete oxidation and long-term stabilization of high-valence Am under practical conditions. This necessitates addressing the complexities of real-world spent fuel reprocessing scenarios (high acidity and radiation level) and minimizing the generation of secondary waste. In this perspective, we outline the most recent advances in lanthanide and actinide separation following redox-based protocols. High Am/Ln separation factors have been achieved in these works via judicious synergy between proper selection of chemical oxidants and stabilization of Am(V)/Am(VI) via complexation or ion sieving. Ongoing efforts to develop oxidation strategies and separation technologies hold the potential to yield an advanced process suitable for application within the nuclear industry. In addition, separation strategies based on oxidation state control holds promise for addressing the even more challenging task of Am/Cm separation in advanced nuclear fuel cycle.