Mesoporous metal-organic frameworks (meso-MOFs) have attracted much attention due to their potential applications in catalysis, energy storage and other fields, but the precise control of their mesostructures still faces challenges. Existing strategies (such as extending ligands or introducing defects) can partially expand the pore size, but it is difficult to achieve long-range ordered mesoporous-microporous synergistic structures. The soft template method can construct mesopores by co-assembling micelles and MOF subunits, but the strong interaction between micelles and coordination units often leads to an imbalance between the crystallinity of the MOF framework and the order of the mesopores, resulting in most meso-MOFs presenting polycrystalline or disordered mesoporous structures. This emerging topic proposes a "strong/weak acid synergistic mediated kinetic matching strategy" to successfully prepare single-crystalline mesoporous MOFs nanoparticles by regulating the competitive process between MOF crystallization and micelle assembly. The material has both microscopic single crystal frameworks and two-dimensional hexagonal ordered mesopores (pore size 9.1–40 nm), and the particle size (45 nm–1 μm), morphology (octahedron, nanosheet, etc.) and composition (multi-metal/ligand) can be precisely controlled. This method provides a new paradigm for the rational design of hierarchical porous materials and demonstrates excellent ion transport and stability in zinc-ion batteries, highlighting its functional application prospects.