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Crystalline porous organic frameworks: Emerging platforms for enzyme immobilization in biomedical applications
Xueting Hu, Lijia Zhao*, Tingting Liao, and Cheng-Peng Li*
https://doi.org/10.1016/j.cjsc.2025.100793
ABSTRACT
Crystalline porous organic frameworks (CPOFs), with their highly ordered pores and tunable organic structures, have shown immense promise as platforms for enzyme immobilization. However, research on enzyme@CPOF composites, particularly for biomedical applications, is still in its early stages and lacks comprehensive and systematic review. This article provides a thorough overview of recent advances in the rational design, synthesis, and application of enzyme@CPOF biocomposites. Emphasis is placed on immobilization strategies and the structure-performance relationships revealed through molecular-level investigations. Furthermore, we highlight emerging applications in biocatalysis and biomedical engineering, and discuss persistent challenges and future directions to advance CPOFs as versatile, high-performance substrates for enzyme immobilization.
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