Modulation of zeolite porosity, including the size and type of channel and cage, is essential for catalysis and separation. Although zeolites with a variety of porous systems have been synthesized by hydrothermal or post-synthetic routes, there was still a lack of rational control of zeolite porosity in the range of large to medium pore/cage. Herein, based on the rational structure building, the structure similarity between IWV topology with large-pore opening and supercage and NES topology with medium-pore opening and medium cage was discovered. Based on the guidance of structure building, two IWV-derived daugther zeolites with different framework compositions, (Si,Ge)-ECNU-31 and (Si,Ge,Al)-ECNU-31, were hydrothermally prepared with built-in structural weakness due to the presence of a large amount of framework Ge atoms, which were utilized to prepare ECNU-32 zeolite with NES topology through subsequent post-synthetic treatment under controlled condition. It was demonstrated that the parent IWV zeolite with only Ge and Si as framework atoms was benefit in post-treatment to obtain a highly crystalline NES zeolite. In constrast, the co-existence of framework Al atoms in (Si,Ge,Al)-ECNU-31 zeolite enhanced its hydrothermal stability in water. However, the treatment with acid and amine solutions caused the partial collapse of zeolite structure. Our results demonstrated that rational selection of the framework composition and post-synthetic parameters were crucial for the transformation of large-pore zeolite to medium-pore zeolite.