Silver nanoparticles (AgNPs) are widely adopted in polyurethane foams (PUFs) as a type of antibacterial agent. However, due to its poor interfacial interaction, AgNPs are difficult to be dispersed in the polymer matrix uniformly, which deteriorates the enhancement effect. In this paper, silver-coated graphene nanocomposite (Ag/GO) is prepared by an enzyme reductant which is efficient and non-toxic. Compared with traditional antibacterial agent, the Ag/GO nanoparticles can be uniformly dispersed in the nanocomposite, which means that Ag/GO can be well- dispersed into the polyurethane foams (PUFs). Compared with AgNPs modified PUFs, the as-prepared Ag/GO modified PUFs have a 1.85% improvement in resilience, 7.9% improvement in tensile strength, 6.52% improvement in tensile elongation, and 8.74% improvement in bacteriostats rate at a loading of 0.4%.